ISS has historically specialized in lifetime fluorescence measurements using the frequency domain method of determining lifetime events. This approach ultimately yields results faster than working in the time domain, and also makes measurements with a higher degree of sensitivity. Higher acquisition rates and sensitvity are both useful for working with fragile proteins. In addition to their well-known frequency-domain lifetime spectrometers, ISS now makes a full family of fluorescence microscopy tools.

Alba FCS: Fluorescence Correlation Spectrometer - Spectroscopy on Single Molecules

Alba is a dual channel spectrometer that combines a confocal scanning microscope with fluorescence correlation spectroscopy (FCS) and is optimized for both single-photon and multi-photon excitation.

Applications

• Measurement of molecular dynamics
  
• Measurement of kinetic rate constants
  
• Antibody-antigen interactions
  
• Ligand-receptor interactions
  
• Nucleic acid hybridization
  
• Molecular aggregation and polydispersity

Alba FLIM: Confocal Lifetime Imaging

Alba FLIM™ is an automated instrument specifically designed for combination with confocal imaging applications, using either single- or multi-photon fluorescence excitation. Alba FLIM leverages the high sensitivity and fast acquisition speeds that are associated with frequency-domain lifetime methods.·

• Fluorescence Lifetime Images (FLIM)
  
• Fluorescence Resonance Energy Transfer (FRET) efficiency images
  
• Fluorescence images
  
• Raster imaging correlation spectroscopy (RICS)
  
• Steady-state polarization and ratio imaging

PC: Photon Counting Spectrofluorimeter

PC1™ offer high-sensitivity measurements within a compact, computer-controlled Photon Counting Spectrofluorimeter, designed for applications in physical chemistry, biochemistry, physiology, neurochemistry, molecular biology, environmental analysis, and immunoassay research.

Chronos: The affordable solution for picosecond lifetime measurements

Chronos™ is a frequency-domain instrument that uses laser diodes and light emitting diodes (LEDs). This powerful tool offers most of the benefits of a full laser-sourced time-resolved fluorometer, and it is also a fully-automated instrument.

K2: A Multi-frequency, Cross-Correlation, Phase and Modulation Fluorometer

With over 100 installed units all over the world, the K2™ family of Multifrequency Cross-Correlation Phase and Modulation Fluorometers represents a solid and well-proven approach to fluorescence and phosphorescence instrumentation for the research laboratory. Its optical design and automatic instrument control are state-of-the-art for steady-state and time-resolved fluorescence measurements.